The Business Operations Center's (BOC) mission is to provide overall leadership, guidance, supervision and coordination of a variety of administrative programs designed to assure the timely and cost-effective accomplishment of agency missions. These services include, but are not limited to, including, employee safety and occupational health, workers' compensation services, mail management, facilities and real property management, personal property management, fleet and sustainability management, and library and information services.  BOC, through its property oversight and management and safety and occupational health functions, supports the Assistant Secretary for Administration and Management (ASAM) in his roles as Senior Real Property Officer and the Designated Agency Safety and Health Official.

The operations of BOC are carried out by five business units: the Office of Support Services (OSS), Office of Worker Safety, Health and Environment (OWSHE), Office of Facility Operations (OFO), Office of Real and Personal Property (ORPP) and the Wirtz Labor Library.